Immunology of Clinical and Experimental Diabetes

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Immunology of Clinical and Experimental Diabetes | JAMA | JAMA Network

Loss of gut barrier integrity triggers activation of islet-reactive T cells and autoimmune diabetes. PNAS Jun Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation.

Diabetes - Clinical Presentation

Nat Med. Nat Commun. The study unveiled new survival strategies implemented by tumor cells as a result of transplantation and could have direct implications for the clinical treatment of AML relapses. The study is among the first to trace a direct link between intestinal microbiota and a tumor located in a different organ.

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Researchers discovered a novel biological function for the so called conduit system inside lymph nodes. A research fellow position is immediately available at the Viral Evolution and Transmission Unit, headed by Gabriella Scarlatti.

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  5. We are looking for a postdoc to work on the role of the cross-talk between gut microbial strains and autoimmune T cells in the pathogenesis of extraintestinal autoimmune diseases. Home Divisions Immunology, Transplantation….

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    Immunology of Clinical and Experimental Diabetes

    Our team is probing the molecular causes of this disease with the aim of using this knowledge to create new therapeutics for the treatment of type I diabetes mellitus. Indeed with this aim in mind; in one aspect of our work we have discovered novel genes that control how insulin-producing cells die when they are attacked by the immune system.

    For this study we are analysing the genes of people who have type 1 diabetes and also a diabetic complication including hypoglycaemia unawareness. Our aim is to now take these findings further towards human trials. There are many people with type 1 diabetes and some will also develop complications.

    Paolo Dellabona

    Ultimately, our goal is to overcome these obstacles and make a significant contribution to human health.